Glimepiride Medication: Dosage, Indications, & Contraindications


Many drugs are usually prescribed by doctors for patients with diabetes mellitus or type two diabetes, one of which is the drug Glimepiride. What drug is Glimeperide? The drug Glimepiride is a drug for controlling high blood sugar levels for people with type two diabetes. The drug Glimepiride is a drug that is given for the treatment of patients suffering from diabetes. Then, did you know about the composition of Glimepiride, the benefits of Glimepiride, the function of Glimepiride, and the dose of Glimepiride?

The benefits of Glimepiride are to encourage the pancreas to produce and use insulin in the body more efficiently. While the function of Glimepiride is to prevent kidney failure, heart attack, diabetic retinopathy or stroke which is a complication of diabetes. The composition of Glimepiride is in each tablet containing Glimepiride.

Once you know what drug Glimepiride is, you should find out more information about the dose of Glimepiride, an indication of the drug Glimepiride, and the contraindications to the drug Glimepiride. Let’s see more information about the Glimepiride drug below.

Name : Glimepiride
Group : Antidiabetic, Sulfonilurea
Trade name : Amaryl

Dose of Glimepiride and Indications for Adults

For type 2 diabetes mellitus

Initial dose: 1 – 2 mg PO every morning after breakfast or when eating first; dosage can be increased by 1 – 2 mg every 1 – 2 weeks; do not exceed 8 mg / day

If you want to replace oral diabetes mellitus medications:
Observe the patient with caution in 1 – 2 weeks when replacing long-half-time sulfonylurea to glimepiride, because the effects of hypoglycemia can overlap and endanger the patient

Consideration of the dose of Glimepiride
Use it as monotherapy (single therapy), or if the glycemic response to glimepirid medication is still lacking when the maximum dose has been given, use insulin or metforin

Modification of Glimepiride dosage:
If there is renal impairment: 1 mg orally per day, changes in dosage are based on fasting sugar levels
If there is a liver disorder: there is no study, it is not recommended for severe liver disorders, start therapy at a dose of 1 mg orally per day

Dosage of Glimepiride and Indications for Geriatrics

The incidence of prolonged hypoglycemia with the use of glimepiride has been reported; conservative dose titration, watch for symptoms of hypoglycemia or hyperglycemia
For type 2: 1 mg diabetes mellitus orally every day; dose titration at intervals every week to prevent hypoglycemia

Side Effects The use of Glimepiride Medication is:

Side effects of Glimeperide drug with a frequency of> 10%

  • Hypoglycemia (4-20%)

Side effects of Glimepiride drug with a frequency of 1-10%

  • Dizziness (1.7%)
  • Asthenia (1.6%)
  • Headache (1.5%)
  • Nausea (1.1%)

Side effects of Glimepiride drug with a frequency of <1%

  • Skin allergic reactions
  • Erythema
  • Morbiliformis or maculopapular eruption
  • Pruritus
  • Urticaria
  • Diarrhea
  • Gastrointestinal pain
  • Gag
  • Agranulocytosis
  • Anemia
  • Aplastic anemia
  • Leukopenia
  • Pancytopenia
  • Thrombocytopenia , hemolytic
  • Cholestasis
  • Increased liver enzyme levels
  • Hepatic porphyria reaction
  • Jaundice (rare)
  • Disulfiram-like reactions
  • Hyponatremia

Post Marketing Report on Glimepiride Medication

  • Serious hypersensitivity reactions, including anaphylaxis, angioedema, and Stevens Johnson Syndrome
  • Hemolytic anemia in patients with and without G6PD deficiency
  • Liver disorders (for example, cholestasis, jaundice) and hepatitis , which can progress to liver failure
  • Porphyria cutanea tarda, photosensitivity reactions and allergic vasculitis
  • Leukopenia, agranulocytosis, aplastic anemia, and pancytopenia
  • Thrombocytopenia (including severe cases with platelet counts <10,000 / MCL) and thrombocytopenic purpura
  • Hepatic porphyria reaction and disulfiram-like reaction
  • Hyponatremia and SIADH, most commonly in patients given other drugs or medical conditions known to cause hyponatremia or an increase in antidiuretic hormone release

Contraindications to the use of the drug Glimepiride

  • The presence of hypersensitivity; sulfa allergy
  • Type 1 diabetes
  • Diabetic ketoacidosis (with or without coma)
  • Gestational gestational diabetes mellitus


  • Patients at risk of severe hypoglycemia: Elderly, physically weak, or malnourished; or the presence of adrenal insufficiency or pituitary insufficiency; patients with physical stress due to infection, fever, trauma, or surgery
  • If the patient is exposed to physical stress, it may be necessary to stop glimepiride and start insulin
  • Use caution with liver / kidney damage
  • Pregnancy, breastfeeding
  • Increased risk of cardiovascular mortality
  • People who are allergic to other sulfonamide derivatives can develop an allergic reaction to glimepiride
  • Hypoglycemia may be difficult to recognize in patients with autonomic neuropathy
  • Hemolytic anemia can occur with glucose 6-phosphate dehydrogenase deficiency (G6PD) when treated with sulfonylurea agents
  • Fluid retention, which can worsen or cause heart failure, can occur
  • The combination used with insulin and used in patients with congenital heart failure NYHA class I and II can increase the risk of other cardiovascular effects

Use of Glimepiride Medication in Pregnancy and Breastfeeding Conditions

Safety for pregnancy: Category C.

Types of drug categories for pregnancy:

  • Category A : Generally acceptable, has been through research in pregnant women, and shows no evidence of fetal damage
  • Category B : May be accepted by pregnant women, has been through research in experimental animals but there is no direct research evidence in humans.
  • Category C : Use carefully. Research in experimental animals shows risk and there is no direct research in humans
  • Category D : Used if there are no other drugs that can be used, and in life-threatening conditions.
  • Category X : Don’t use it in pregnancy.
  • NA Category : No information

It is not recommended for breastfeeding mothers because there is no further adequate data on whether or not the drug enters breast milk.